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. 2023 Oct 18;45(2):2267138. doi: 10.1080/0886022X.2023.2267138

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 1. — The network diagram Illustrates the clustering relationship of clinical factors within IgAN-NS and IgAN-NR. Each factor is represented by a node, with orange nodes representing IgAN-NS and light blue nodes representing IgAN-NR. Nodes that are linked by solid black lines indicate a stronger correlation and form a cluster, while nodes that are linked by solid gray lines represent the same factors from various groups (assigned a small weight for the same factors and a larger weight for different factors). to further analyze the clusters, including the factor ‘proteinuria’ in both cohorts, a cluster analysis was conducted using a heatmap. The heatmaps depict the correlation coefficients (pearson’s-correlation-coefficient for linear data) of the clinical factors within IgAN-NS and IgAN-NR. The color scale below the heatmap indicates that darker shades represent positive correlations, whereas lighter shades represent negative correlations. Factors with similar colors are considered to be related or share similar correlations. Alb: serum albumin; BMI: body mass index; eGFR: estimated glomerular filtration rate; Hb: hemoglobin; HDL: HDL-cholesterol; LDL: LDL-cholesterol; MAP: mean blood pressure; s-Cr: serum creatinine; TC: total cholesterol; TG: triglyceride; s-UA: serum uric acid; CRP: C-reactive protein; s-IgA: serum IgA; uRBC: urinary red blood cell counts; uWBC: urinary white blood cell counts; s-Glomeruli: proportion of glomerulosclerosis; IgAN-NS: the IgAN with NS; IgAN-NR: the IgAN with nephrotic-range proteinuria.