FIGURE 4.

Heatmap of associations of the 48 pulmonary hypertension (PH)-related eicosanoid and eicosanoid-related metabolites with pulmonary vascular function. Colour coding represents the standardised β coefficient in the primary model (xsd change in exercise trait per 1sd change in eicosanoid metabolite). Primary analyses are adjusted for age, sex, plate number, statin use and aspirin use. Clustering is based on pulmonary vascular traits (columns). Colour scale indicates positive associations in red and negative associations in blue. Metabolites annotated by mass-to-charge (m/z) ratio/retention time (min) unless identity is known (table 2). mPAP: mean pulmonary arterial pressure; CO: cardiac output; PVR: pulmonary vascular resistance; TPG: transpulmonary gradient; α: pulmonary vascular distensibility; PAC: pulmonary artery compliance.