Table 3. In vitro Anti-Plasmodial Activity against the P. falciparum N54 Strain and Cytotoxicity toward Cells Chinese Hamster Ovarian (CHO) and Hepatocellular Carcinoma (HepG2)a.
| compound | PfN54 IC50 (μM) | CHO IC50 (μM) | CHO SI | HepG2 IC50 (μM) | HepG2 SI | solubility at pH 6.5 (μM) |
|---|---|---|---|---|---|---|
| FM1 | 2.80 ± 0.95 | 32.88 | 11.7 | 40.25 | 14.38 | 80 |
| FM2 | 0.14 ± 0.04 | >50 | >357 | >50 | >357 | 80 |
| FM4 | 0.92 ± 0.11 | >50 | >54 | 6.98 | >8 | <5 |
| FM6 | 1.76 ± 0.29 | >50 | >28 | 12.82 | 7 | <5 |
| FM5 | 1.97 ± 0.44 | >50 | >25 | 0.84 | 0 | 80 |
| F10 | 3.86 ± 2.14 | >50 | >13 | >50 | >13 | ND |
| F12 | 4.50 ± 1.50 | >50 | >11 | >50 | >11 | ND |
| F11 | 6.00 ± n/a | >50 | >8 | >50 | >8 | ND |
a
ND = not determined.