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. 2023 Oct 16;11:e16243. doi: 10.7717/peerj.16243

Table 2. The top ten upregulated DEGs and downregulated DEGs of GC-NAG and IM-NAG.

GC-NAG IM-NAG Regulation
Gene log 2 (FC) P P.adjust Gene log 2 (FC) P P.adjust
Top ten up-regulated DEGs
SERPINE1 6.07 3.52E−38 7.27E−34 OTOP3 6.95 2.37E−32 4.48E−28 Up
ADAMTS4 6.63 7.12E−36 7.35E−32 HEPH 4.63 6.55E−32 6.18E−28 Up
WNT2 14.35 4.27E−29 2.94E−25 SLC39A5 4.86 5.87E−26 3.69E−22 Up
ATP1B3 3.1 6.44E−28 3.32E−24 HOXA13 14.06 6.73E−25 3.18E−21 Up
CCN1 6.2 1.39E−27 5.72E−24 CDH17 6.83 3.49E−24 1.32E−20 Up
MARCO 9.28 3.50E−27 1.13E−23 TINAG 14.63 8.47E−24 2.37E−20 Up
COL4A1 4.31 3.82E−27 1.13E−23 ONECUT2 5.07 8.78E−24 2.37E−20 Up
HEPH 3.94 1.00E−26 2.58E−23 MYO7B 6.80 1.56E−22 3.68E−19 Up
COL6A3 4.26 4.82E−26 1.04E−22 CPS1 7.40 2.80E−22 5.88E−19 Up
RGS1 5.42 5.04E−26 1.04E−22 ADH6 5.08 3.97E−22 7.50E−19 Up
Top ten down-regulated DEGs
ABCC5 −2.09 2.65E−24 2.28E−21 AMY2A −13.77 6.75E−07 4.04E−05 Down
RPTN −9.5 6.62E−24 5.46E−21 CTRC −6.76 2.02E−06 1.08E−04 Down
SLC7A8 −2.78 2.07E−23 1.58E−20 SYCP2 −1.61 6.26E−06 2.88E−04 Down
FLG2 −11.9 1.69E−22 9.68E−20 CASR −1.73 6.55E−06 2.99E−04 Down
SYTL2 −2.64 3.97E−22 2.15E−19 CYP2AB1P −1.52 9.28E−06 4.09E−04 Down
CHAD −3.48 2.60E−21 1.28E−18 SUCNR1 −1.85 1.26E−05 5.32E−04 Down
ALDOC −3.19 2.14E−20 9.01E−18 SYCN −13.53 1.36E−05 5.68E−04 Down
SMIM14 −1.79 5.69E−20 2.13E−17 CAMK2B −1.71 1.37E−05 5.68E−04 Down
SGSM3 −1.89 3.11E−19 1.05E−16 PAX6 −1.67 1.87E−05 5.68E−04 Down
RNASE4 −2.07 4.64E−19 1.49E−16 CPLX2 −2.24 1.90E−05 7.44E−04 Down

Notes.

DEGs
differentially expressed genes
FC
fold change