Table 1.
Study population and paracingulate status
| Entire population | Penn FTDC | Amsterdam Dementia Cohort | P-value | |
|---|---|---|---|---|
| Participants | 186 | 94 | 92 | |
| Age, mean (SD), years | 63.28 (8.32) | 63.15 (8.82) | 63.38 (7.98) | 0.87 |
| Age at onset, mean (SD), years | 59.15 (8.4) | 58.16 (8.29) | 60.14 (8.43) | 0.11 |
| Sex | 113M: F73 | 59M: 35F | 54M: 38F | 0.54 |
| Education,a years (SD) | 13.34 (3.79) | 15.88 (2.74) | 10.63 (2.72) | <000.1 |
| Handedness, No. | 0.69 | |||
| Right | 146 | 81 | 65 | |
| Left | 12 | 9 | 3 | |
| Ambidextrous | 5 | 4 | 1 | |
| Unknown | 23 | 0 | 23 | |
| Diagnostic classification,b No | ||||
| Possible | 8 | 8 | 0 | |
| Probable | 140 | 51 | 89 | |
| Definite | 26 | 24 | 2 | |
| Unknown | 11 | 11 | 0 | |
| MMSE, mean (SD) | 24.18 (5.35) | 23.63 (6.07) | 24.8 (4.35) | 0.14 |
| FTLD-CDR sum of boxes, mean (SD) | 7.51 (3.83) | 9.01 (3.74) | 6.71 (3.65) | 0.001 |
| FTLD-CDR global scores, mean (SD) | 1.59 (0.72) | 1.79 (0.59) | 1.45 (0.76) | 0.01 |
| Hemispheric PCS, No. (%) | ||||
| Left present | 145 (78) | 73 (78) | 72 (78) | 1 |
| Left prominent | 59 (32) | 28 (30) | 31 (34) | 0.68 |
| Right present | 106 (57) | 58 (62) | 48 (52) | 0.53 |
| Right prominent | 31 (17) | 18 (19) | 13 (14) | 0.47 |
| Deceased,c No. (%) | 112 (60) | 51 (56) | 61 (66) | 0.13 |
| Age at death, mean (SD), years | 67.19 (8.86) | 67.42 (9.14) | 66.92 (8.62) | 0.79 |
Demographic and results data for entire population and according to cohort, Penn FTDC (The University of Pennsylvania Frontotemporal Degeneration Centre, PA, USA) and Alzheimer Center of the VU University Medical Center, Amsterdam (Amsterdam Dementia Cohort).26 Sex data: male (M); female (F). present = PCS length ≥ 20 mm, prominent = PCS length ≥ 40 mm. Frequency. t-Tests and chi-squared tests were performed to evaluate differences in continuous and nominal data, respectively.
SD, standard deviation; MMSE, Mini Mental State Examination; FTLD-CDR, Frontotemporal Lobar Degeneration-modified Clinical Dementia Rating;36 Sum, sum of boxes; Global, global score; Hemispheric PCS, hemispheric paracingulate sulcus.
aEducation, years data available for 94/94 Penn FTDC and 88/92 Amsterdam Dementia Cohort.
bDiagnostic classification according to revised International bvFTD Consortium criteria.27
cSurvival data were available for 185/186 individuals.