. Author manuscript; available in PMC: 2023 Oct 19.

Published in final edited form as: J Med Chem. 2023 Mar 31;66(7):5079–5098. doi: 10.1021/acs.jmedchem.3c00009

Table 3.

Activity data against the MMV688845 resistant strain Mabs Bamboo 845^R-2.1. (generated by selecting at 50 μM MMV688845 using Mabs Bamboo). This strain is resistant to MMV688845 and has a RpoB P473L mutation³⁴. The observed frequency of resistance (FoR) was 5.83 x 10⁻⁸ CFU⁻¹. CLR: clarithromycin; RFB: rifabutin)

	MIC₉₀ (μM)
	Mabs Bamboo 845^R-2.1
	7H9
CLR	0.27
RFB	1.1
MMV688845	>100
24	42
14	>100
15	100