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. Author manuscript; available in PMC: 2023 Oct 19.
Published in final edited form as: J Med Chem. 2023 Mar 31;66(7):5079–5098. doi: 10.1021/acs.jmedchem.3c00009

Table 6.

Kinetic solubilities and cLogP values of all synthetized AAP derivativesA

MMV845 6 7 11 12 14 15
Solubility [μM] 82 34 28 37 31 271 431
cLogP 3.72 4.45 4.62 4.6 4.78 2.49 2.67
 
17 18 20 24 28 29 32
Solubility [μM] 131 184 62 64 70 32 39
cLogP 2.65 2.83 2.54 2.71 2.7 2.87 4.87
 
34 36 37 39 40 42 43
Solubility [μM] 85 78 58 170 158 30 31
cLogP 2.96 4.21 4.39 2.31 2.48 3.65 3.83
 
45 46 50 51 53 54
Solubility [μM] 41 39 74 96 60 96
cLogP 3.53 3.71 2.42 2.59 2.3 2.48
A

Color coding: The colors show the difference to the average kinetic solubility of all tested compounds, dark blue: highest solubility; light blue: above average; white: closest to average; light red: below average, dark red: lowest kinetic solubilities of the tested compound set.