Table 2.
Sensitivity and specificity of serum ACE in different types of sarcoidosis.
| Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
|---|---|---|---|---|
| Sarcoidosis | ||||
| serum ACE | 22–86 | 54–95 | – | – |
| Ocular sarcoidosis (n = 249) (36) | ||||
| serum ACE ≥68 U/L | 30 | 85 | 26 | 87 |
| serum ACE ≥51 U/L | 54 | 70 | 24 | 90 |
| serum ACE ≥68 U/L + chest radiograph | 70 | 79 | 42 | 92 |
| serum ACE ≥51 U/L + chest radiograph | 82 | 64 | 33 | 94 |
| Ocular sarcoidosis (n = 37) (37) | ||||
| serum ACE | 27 | 96.6 | 90.9 | 51.7 |
| Ocular sarcoidosis (n = 22) (38) | ||||
| serum ACE | 73 | 83 | – | – |
| serum ACE + positive 67GA scanning | 100 | 73 | – | – |
| Ocular sarcoidosis (n = 79) (39) | ||||
| serum ACE | 37.7 | 97.5 | – | – |
| Cardiac sarcoidosis (n = 94) (40) | ||||
| serum ACE ≥13.5 IU/L + positive EMB | 56.8 | 54.4 | 44.7 | 66.0 |
| serum ACE ≥13.5 IU/L + positive EMB + LVEF <37% | 37.8 | 91.2 | 73.7 | 69.3 |
ACE, Angiotensin-converting enzyme; EMB, endomyocardial biopsy; LVEF, left ventricular ejection fraction; NPV, negative predictive value; PPV, positive predictive value.