FIG. 2.

Effect of AY on survival (percent change in viable cells from that at the baseline) of PBMCs stimulated with PHA and cultured in complete medium containing recombinant IL-2 in the presence (AY+) or in the absence (AY−) of the drug (3 × 10⁻⁶ M). Data represent cell proliferation in 15-day cultures after stimulation of the cells in the absence or in the presence of AY. The cells were derived from three groups of donors: eight healthy HIV-1-seronegative individuals (group C) (HIV⁻), eight HIV-1-seropositive asymptomatic individuals (group S; CD4⁺ cell count, >500/mm³), and eight AIDS (symptomatic) patients (group M; CD4⁺ cell count, <200/mm³). Results are expressed as percent (10⁻²; means ± SDs of three experimental values).