FIG. 4.

Effect of AY on the survival (A) and superantigen-induced proliferation (B) of PBMCs as a function of the drug concentration. PBMCs were obtained from one representative symptomatic AIDS patient and were stimulated with 0.1 μg of SEB per ml, as described in the legend to Fig. 2. The percent change (10⁻²) in viable cells from that at the baseline was measured after 15 days of culture. Cell proliferation was determined by measuring the level of [³H]thymidine uptake at 6 days after SEB activation. The results are means ± SDs of three experimental values.