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p38-MAPK, JNK, and ERK1/2 signaling were activated by AREG. (a–c) HepG2 cells were incubated with 50 ng/mL AREG for indicated times. Signaling by MAPKs was analyzed using anti-phospho-JNK, anti-phospho-ERK, anti-phospho-p38-MAPK, and anti-actin antibodies. Graphs represent the ratio between the phosphorylated protein and the total amount of the targeted protein. ∗P < 0.05, ∗ ∗P < 0.01, and ∗ ∗ ∗P < 0.001 compared to the time point 0.
