Table 2. Computer-Aided ADMET Parameters of Acrylate Compounds 4b and 5e.
| parameter | 4b | 5e |
|---|---|---|
| BBB_Leva | 3 | 2 |
| absorption Levb | 0 | 0 |
| AQ SOL Levc | 3 | 2 |
| Alog P98d | 1.55 | 3.25 |
| ADME_PSA_lev | 91.51 | 83.132 |
a
Blood brain barrier level; 4 = undefined, 3 = low penetration, 2 = medium penetration, 1 = high penetration.
b
Absorption Level; 3 = very low absorption, 2 = low absorption, 1 = moderate, 0 = good absorption.
c
Aqueous solubility level; 4 = optimal, 3 = good, 2 = low solubility, 1 = very low but soluble, 0 = extremely low.
d
Polar surface area; compounds must have a log p value not greater than 5.0 to attain reasonable probability of being well absorbed.