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. 2023 Oct 4;8(41):38641–38657. doi: 10.1021/acsomega.3c05928

Table 2. Enzyme Inhibition Activities of Compounds 1–26a.

  anticholinesterase activity
        
compound AChE IC50(μM) BChE IC50(μM) SI for AChEb SI for BChEb tyrosinase activity IC50(mM) urease activity IC50(μM)
1 129.95 ± 0.18 118.46 ± 0.34 0.91 1.10 35.13 ± 0.07 82.54 ± 0.29
2 44.30 ± 0.75 66.44 ± 0.41 1.50 0.67 30.25 ± 0.61 65.43 ± 0.67
3 34.22 ± 0.63 48.72 ± 0.18 1.42 0.70 29.44 ± 0.49 56.80 ± 0.15
4 27.65 ± 0.51 39.60 ± 0.74 1.43 0.70 28.41 ± 0.90 56.11 ± 0.22
5 26.99 ± 0.48 37.11 ± 0.57 1.38 0.73 28.04 ± 0.35 55.64 ± 0.81
6 28.95 ± 0.64 36.81 ± 0.19 1.27 0.79 27.99 ± 0.17 50.78 ± 0.08
7 30.45 ± 0.47 40.88 ± 0.16 1.34 0.75 27.72 ± 0.24 54.34 ± 0.62
8 33.61 ± 0.33 47.27 ± 0.77 1.41 0.71 25.68 ± 0.39 53.37 ± 0.64
9 29.80 ± 0.81 40.19 ± 0.19 1.35 0.74 25.42 ± 0.12 51.70 ± 0.12
10 26.48 ± 0.25 37.53 ± 0.20 1.42 0.71 25.00 ± 0.67 49.28 ± 0.55
11 21.45 ± 0.06 32.77 ± 0.48 1.53 0.66 23.41 ± 0.50 31.52 ± 0.49
12 17.41 ± 0.22 24.43 ± 0.51 1.40 0.71 24.78 ± 0.77 23.60 ± 0.70
13 20.05 ± 0.37 32.21 ± 0.11 1.61 0.62 26.16 ± 1.11 30.28 ± 0.95
14 19.21 ± 0.61 25.72 ± 1.05 1.34 0.75 8.10 ± 0.22 26.70 ± 0.52
15 27.40 ± 0.76 37.63 ± 0.61 1.37 0.73 5.19 ± 0.03 46.37 ± 1.08
16 29.04 ± 1.03 42.50 ± 0.18 1.46 0.69 24.08 ± 0.15 42.03 ± 0.81
17 34.76 ± 0.53 49.80 ± 1.01 1.43 0.70 3.22 ± 0.70 40.22 ± 0.12
18 21.44 ± 0.92 32.90 ± 0.75 1.54 0.65 16.04 ± 0.41 20.24 ± 0.77
19 20.59 ± 0.55 29.73 ± 0.72 1.44 0.69 19.28 ± 0.09 18.25 ± 0.50
20 26.84 ± 0.77 34.05 ± 0.06 1.26 0.79 21.45 ± 0.31 16.79 ± 0.19
21 20.65 ± 1.02 28.14 ± 0.55 1.36 0.73 11.16 ± 0.39 27.82 ± 0.51
22 24.78 ± 0.30 33.01 ± 0.84 1.33 0.75 9.13 ± 0.55 26.16 ± 0.47
23 19.73 ± 0.54 25.42 ± 0.26 1.29 0.78 8.05 ± 0.11 24.97 ± 0.54
24 19.52 ± 0.29 25.66 ± 0.69 1.32 0.76 7.21 ± 0.27 22.49 ± 0.11
25 19.80 ± 0.50 25.46 ± 0.78 1.29 0.78 8.40 ± 0.64 21.70 ± 0.06
26 19.84 ± 0.37 25.70 ± 0.53 1.30 0.77 8.76 ± 0.90 21.51 ± 0.44
galantaminec 4.48 ± 0.78 46.03 ± 0.14 10.28 0.10 NT NT
kojic acidc NT NT     0.66 ± 0.42 NT
IQl-mimosinec NT NT     0.70 ± 0.11 NT
thioureac NT NT     NT 24.20 ± 0.3
a

Values expressed are the mean ± SEM of three parallel measurements (p < 0.05).

b

Selectivity index for AChE: IC50 for BChE/IC50 for AChE. Selectivity index for BChE: IC50 for AChE/IC50 for BChE. NT: not tested.

c

Reference compounds.