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. 2023 Aug 3;75(10):1781–1792. doi: 10.1002/art.42538

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© 2023 The Authors. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Summary of the design and results of the current study. This study included 4 major components: 1) meta‐analysis of genome‐wide association study of circulating sclerostin; 2) single trait genetic analysis and functional annotation of the top sclerostin signals; 3) Mendelian randomization and genetic correlation analysis of sclerostin on 15 atherosclerosis‐related diseases and risk factors traits; 4) bidirectional Mendelian randomization analysis of 15 atherosclerosis‐related diseases and risk factors on sclerostin. SNPs = single‐nucleotide polymorphisms; HDL‐C = high‐density lipoprotein cholesterol.