Figure 2.

Adjusted associations between trimester-specific concentrations (ng/mL, ln-transformed SG-adjusted) of maternal urinary mOPPs, mPYRs, and mNNIs over the three trimesters and children’s (A) MDI and (B) PDI scores using generalized estimating equations (GEE) models for participants from a birth cohort study in Wuhan, China, 2014–2017 ($N=\mathrm{1,041}$ participants, $n=\mathrm{1,041}$ samples for each specific trimester). The models were adjusted for maternal age (categorical), PBMI (categorical), maternal education (categorical), passive smoking (categorical), folic acid supplementation during pregnancy (categorical), parity (categorical), child sex (categorical), breastfeeding duration (categorical), delivery mode (categorical), and sampling seasons (categorical). Sex-stratified analyses were adjusted for all the abovementioned confounders except child sex. *$p_{FDR}<0.05$ were considered statistically significant (FDR corrections were performed to adjust for multiple comparisons). Details of chemical abbreviations are provided in Figure 1, and the numerical values are listed in Table S8. Note: FDR, false discovery rate; MDI, mental development index; mNNIs, metabolites of neonicotinoid insecticides; mOPPs, metabolites of organophosphate insecticides; mPYRs, metabolites of pyrethroids; PBMI, prepregnancy body mass index; PDI, psychomotor development index; $p_{FDR}<0.05$, $p$-value for false discovery rate; SG, specific gravity.