TABLE 2.
MICs of β-lactams for P. aeruginosa Mus, E. coli JM109 harboring recombinant plasmid pPL10, and reference strain E. coli JM109
| Antibiotic(s) | MIC (μg/ml) for:
|
||
|---|---|---|---|
| P. aeruginosa Musa | E. coli JM109(pPL10)b | E. coli JM109 | |
| Amoxicillin | >512 | 512 | 2 |
| Amoxicillin-Clac | >512 | 32 | 2 |
| Ticarcillin | 256 | 512 | 2 |
| Ticarcillin-Cla | 64 | 32 | 1 |
| Piperacillin | 64 | 4 | 1 |
| Piperacillin-Cla | 32 | 1 | 0.5 |
| Cephalothin | >1,024 | 32 | 4 |
| Cephalothin-Cla | >512 | 8 | 2 |
| Cefamandole | >512 | 8 | 1 |
| Cefamandole-Cla | >512 | 2 | 1 |
| Cefoxitin | >1,024 | 16 | 8 |
| Cefoxitin-Cla | >512 | 8 | 8 |
| Ceftazidime | 128 | 0.5 | 0.25 |
| Ceftazidime-Cla | 8 | 0.5 | 0.25 |
| Cefotaxime | 128 | 0.06 | 0.06 |
| Cefotaxime-Cla | 8 | 0.06 | 0.06 |
| Cefepime | 16 | 0.12 | 0.06 |
| Cefepime-Cla | 4 | 0.03 | 0.06 |
| Cefpirome | 32 | 0.5 | 0.12 |
| Cefpirome-Cla | 8 | 0.06 | 0.06 |
| Moxalactam | 64 | 0.25 | 0.25 |
| Moxalactam-Cla | 64 | 0.12 | 0.12 |
| Aztreonam | 256 | 0.25 | 0.12 |
| Aztreonam-Cla | 16 | 0.12 | 0.06 |
| Imipenem | 8 | 0.25 | 0.06 |
| Imipenem-Cla | 8 | 0.25 | 0.06 |
a
P. aeruginosa Mus produces the restricted-spectrum β-lactamase OXA-20 along with an extended spectrum β-lactamase OXA-18 and an undetermined cephalosporinase.
b
E. coli JM109 harboring recombinant plasmid pPL10 produced the studied β-lactamase.
c
Cla, clavulanic acid at a fixed concentration of 2 μg/ml.