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Sensitivities and specificities of potential DNA methylation markers for the detection of esophageal cancer in the training cohort.
| Sensitivity (95% CI, %) | Specificity (95% CI, %) | Youden index (%) | PPV (%) | NPV (%) | |
|---|---|---|---|---|---|
| △Ct ZNF582 | 43.8 (29.8–58.7) | 93.1 (85.6–96.9) | 36.9 | 75.0 | 77.7 |
| △Ct FAM19A4 | 25.0 (14.1–39.9) | 90.1 (82.1–94.9) | 15.1 | 54.5 | 71.6 |
| △Ct ZNF582 + △Ct FAM19A4 | 60.4 (45.3–73.9) | 83.2 (74.1–89.6) | 43.6 | 63.0 | 81.5 |
PPV, positive predictive value; NPV, negative predictive value.
