Fig. 4.

Geometric mean metformin blood concentration versus time profiles for metformin after intravenous administration to mice (insets are semi-logarithmic plots). A single intravenous dose of metformin (5 mg/kg) was administered alone (black closed circles) 30 minutes after a single oral dose of (A) goldenseal extract (gold squares) (500 mg/kg) or (B) imatinib (100 mg/kg) (purple diamonds). Symbols and error bars denote geometric means and S.D.s, respectively, in the absence or presence of test articles (n = 7 per group).