TABLE 3.
Pharmacokinetics of intravenous metformin alone (presence of vehicle) or in the presence of orally administered goldenseal extract or imatinib in mice
| Vehicle | Goldenseal extract | Imatinib | |
|---|---|---|---|
| AUC0-12h (µM·h) | 5.5 (31) | 7.0 (18) | 6.7 (18) |
| AUCR0-12h | NA | 1.27 (1.10–1.48) | 1.20 (0.97–1.50) |
| AUCinf (µM·h) | 5.7 (30) | 7.1 (19) | 6.8 (18) |
| t1/2 (h) | 1.4 (34) | 1.7 (18) | 1.9 (39) |
Values are geometric means (CV%) unless indicated otherwise. Geometric means (90% confidence intervals). AUC0-12h, area under the blood concentration-time curve from 0 to 12 h; AUCinf, AUC from time of dosing extrapolated to infinity based on the last observed concentration; AUCR, ratio of AUC0-12h in presence of test article to vehicle; CV, coefficient of variation; NA, not applicable; t1/2, elimination half-life. Sample sizes for all values were n=7.