TABLE 1.
Summary of parameter estimates for sample population
| CYP2D6 Genotype | Vmax (pmol/min/mg protein) |
Km (μM) |
n |
|---|---|---|---|
| *1/*1 | 373.70 ± 62.84 | 1.53 ± 0.26 | 10 |
| *1/*2 | 495.81 ± 83.38 | 1.47 ± 0.25 | 10 |
| *1/*2x2 | 1486.38 ± 249.95 | 1.92 ± 0.32 | 10 |
| *1/*4 | 288.84 ± 48.57 | 0.97 ± 0.16 | 10 |
| *2/*2 | 265.65 ± 44.67 | 4.84 ± 0.81 | 10 |
| *2/*3 | 264.60 ± 44.5 | 1.39 ± 0.23 | 10 |
| *2/*4 | 101.09 ± 17 | 1.77 ± 0.30 | 10 |
| *4/*41 | 32.57 ± 5.48 | 5.64 ± 0.95 | 10 |
| *4/*5 | 12.99 ± 2.18 | 72.9 ± 12.26 | 10 |
Vmax and Km values represent mean ± standard deviation of each genotype group.