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. Author manuscript; available in PMC: 2023 Oct 19.
Published in final edited form as: Med Chem Res. 2021 Apr 6;30(7):1348–1357. doi: 10.1007/s00044-021-02724-7

Scheme 5.

Scheme 5

C4/C6 diastereomer synthons. A aza-Wacker cyclization reaction of primary sulfamate 14. B Using pOMe-phenyl sulfamate 16 dramatically improves the yield of the tethered aza-Wacker cyclization reaction