Table 5.

Top 10 up- and downregulated DEGs identified in mCRC compared to prim CRC; LogFC and corresponding p-values were estimated by the Reactome v83.

Identifier	Regulation	LogFC	p-value	Identifier	Regulation	LogFC	p-value
CEBPB	Up	1398.57	0.007	TAP1	Down	−2,113.43	<0.001
RORA	Up	528.98	0.007	OAS1	Down	−1,425.43	<0.001
IFI30	Up	5470.27	0.009	TAPBP	Down	−1,487.27	<0.001
NFKBIA	Up	7301.55	0.013	ELK1	Down	−324.75	<0.001
LY96	Up	516.91	0.016	FADD	Down	−454.94	<0.001
MICA	Up	405.78	0.020	CCRL2	Down	−324.96	<0.001
MYD88	Up	771.50	0.027	SIGIRR	Down	−718.52	<0.001
C5	Up	380.02	0.027	PPARG	Down	−2,518.31	<0.001
HLA−DPA1	Up	5721.58	0.037	IRF2BP1	Down	−164.00	<0.001
IFITM3	Up	21922.69	0.037	PPIL2	Down	−672.46	<0.001