Table 2.
Genotype distribution of the c.180C>T (p.Gly60=) CTRC variant in the Hungarian and pan-European CP cohorts. Genotypic OR values were calculated for the c.180TT and c.180CT (shown in italics) genotypes. OR, odds ratio, CI, confidence interval
| Hungarian CP cohort | c.180C>T genotype | OR | 95% CI | p-value | ||
|---|---|---|---|---|---|---|
| CC | CT | TT | ||||
| ACP (n=167) | 110 (65.9%) |
53 (31.7%) |
4 (2.4%) |
10.15 | 1.12-91.79 | 0.039 |
| 1.95 | 1.28-2.97 | 0.002 | ||||
| NACP (n=124) | 83 (66.9%) |
34 (27.4%) |
7 (5.7%) |
23.53 | 2.85-194.01 | 0.003 |
| 1.66 | 1.03-2.67 | 0.039 | ||||
| Total CP (n=291) | 193 (66.3%) |
87 (29.9%) |
11 (3.8%) |
15.90 | 2.04-124.18 | 0.008 |
| 1.82 | 1.26-2.63 | 0.001 | ||||
| Controls (n=349) | 279 (79.9%) |
69 (19.8%) |
1 (0.3%) |
|||
| Pan-European CP cohort (Rosendahl et al., 2018) |
||||||
| ACP (n=1792) | 1259 (70.3%) |
490 (27.3%) |
43 (2.4%) |
2.37 | 1.61-3.49 | < 0.0001 |
| 1.86 | 1.64-2.11 | < 0.0001 | ||||
| NACP (n=544) | 368 (67.6%) |
151 (27.8%) |
25 (4.6%) |
4.71 | 2.94-7.54 | < 0.0001 |
| 1.96 | 1.61-2.40 | < 0.0001 | ||||
| Total CP (n=2336) | 1627 (69.7%) |
641 (27.4%) |
68 (2.9%) |
2.90 | 2.06-4.07 | < 0.0001 |
| 1.89 | 1.68-2.11 | < 0.0001 | ||||
| Controls (n=5768) | 4715 (81.2%) |
985 (17.1%) |
68 (1.2%) |
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