Figure 3. Lys acylations are structurally diverse yet display significant redundancy in modification sites.

Proteomic inventories were mined to reveal a striking overlap in modification sites. While many of these sites are surface-exposed, some display a high propensity to modification despite being stearically hindered (e.g. Lys343 on ENO1 and Cys152 on GAPDH). PTM sites were curated from [44,92,116–120,141–147]. ENO1 (PDB: 2SPN) and GAPDH (PDB:3GPD).