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. 2023 Aug 31;136(20):2412–2420. doi: 10.1097/CM9.0000000000002800

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Copyright © 2023 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0

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Major OS-related signaling pathway. Mediation of genes, inhibitor of target genes, natural compounds, IncRNA and microRNA can participate in the regulation of OS-related signaling pathways including Wnt/β-catenin, PI3K/AKT, HH, Notch and MAPK/ERK signaling pathways, thereby inhibiting the malignant behavior of OS. HH: Hedgehog; LncRNA: Long non-coding RNA; MAPK/ERK: Mitogen-activated protein kinase/extracellular regulated protein kinase; OS:Osteosarcoma; PI3K/AKT: Phosphatidylinositol 3 kinase/protein kinase B.