Table 1.
Hypoxia and acidosis in the bone microenvironment promote the metastasis of OS.
| Conditions | Genes | Interacting molecules | Efficacy | Reference |
|---|---|---|---|---|
| Hypoxia | MSTO2P | PD-L1 | Proliferation, invasion, and EMT↑ | [17] |
| Bcl-2 | MicroRNA-15a | Migration and invasion ↑ | [18] | |
| MicroRNA-33b | Proliferation and invasion↑ | [19] | ||
| IncRNA-FOXD2-AS1 | Proliferation and invasion↑ | [20] | ||
| PDGF/PDGFR | Proliferation and migration↑ | [21] | ||
| Acidity | CXCL1, CXCL2, CXCL4,CXCL5, IL-6, IL-8 | – | Growth and metastasis↑ | [22] |
EMT: Epithelial-to-mesenchymal-transition; OS: Osteosarcoma; PD-L1: Programmed cell death-ligand 1; PDGF: Platelet-derived growth factor; PDGFR: PDGF receptor.