Table 2.
Meta-analysis results of the association between SNPs in UGT1A1/UGT2B7 and AT-DILI risk under the allele model.
| Genes | Country | SNPs | Study numbers | Heterogeneity test | Overall effect | |||
|---|---|---|---|---|---|---|---|---|
| χ 2 | P | I 2 | OR (95% CI) | P | ||||
| UGT1A1 | All | rs4148323 (G> A) | 5 | 5.64 | 0.228 | 29 | 0.983 (0.811–1.191) | 0.857 |
| All | rs2003569 (G> A) | 2 | 0.00 | 0.993 | 0 | 0.989 (0.784–1.247) | 0.923 | |
| All | rs8330 (C > G) | 2 | 0.44 | 0.506 | 0 | 0.852 (0.681–1.065) | 0.159 | |
| All | rs4148328 (T > C) | 2 | 5.66 | 0.017 | 82 | 0.988 (0.711–1.375) | 0.945 | |
| All | rs3755319 (A > C) | 2 | 0.66 | 0.415 | 0 | 1.044 (0.852–1.280) | 0.677 | |
| China | rs4148323 (G> A) | 4 | 5.40 | 0.145 | 44 | 0.982 (0.777–1.242) | 0.881 | |
|
| ||||||||
| UGT2B7 | China | rs7662029 (A > G) | 2 | 0.01 | 0.938 | 0 | 1.547 (1.249–1.917) | <0.001 |
| China | rs7439366 (T > C) | 2 | 0.23 | 0.632 | 0 | 0.585 (0.477–0.717) | <0.001 | |
UGT1A1, UDP-glucuronosyltransferase 1A1; UGT2B7, UDP-glucuronosyltransferase 2B7; AT-DILI, antituberculosis drug-induced liver injury; SNPs, single nucleotide polymorphisms; OR, odds ratio; 95% CI, 95% confidence interval.