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. 2023 Oct 12;2023:5044451. doi: 10.1155/2023/5044451

Table 3.

Meta-analysis results of the association between SNPs in UGT1A1/UGT2B7 and AT-DILI risk under different genetic models.

Genes Country SNPs Study numbers Dominant model Recessive model Homozygote model Heterozygote model
Heterogeneity test Overall effect Heterogeneity test Overall effect Heterogeneity test Overall effect Heterogeneity test Overall effect
χ 2 P I 2 OR (95% CI) P χ 2 P I 2 OR (95% CI) P χ 2 P I 2 OR (95% CI) P χ 2 P I 2 OR (95% CI) P
UGT1A1 All rs4148323 (G> A) 5 4.24 0.374 6 0.989 (0.824–1.188) 0.909 5.55 0.238 28 0.775 (0.432–1.391) 0.393 5.97 0.204 33 0.780 (0.419–1.452) 0.433 3.03 0.552 0 1.017 (0.851–1.216) 0.852
All rs2003569 (G> A) 2 0.00 1.000 0 0.970 (0.740–1.272) 0.824 0.01 0.929 0 1.090 (0.574–2.070) 0.793 0.01 0.927 0 1.075 (0.562–2.054) 0.828 0.00 0.994 0 0.956 (0.720–1.269) 0.756
All rs8330 (C > G) 2 0.71 0.399 0 0.827 (0.634–1.079) 0.161 0.06 0.813 0 0.908 (0.553–1.491) 0.730 0.00 0.956 0 0.824 (0.499–1.361) 0.450 0.90 0.342 0 0.825 (0.617–1.104) 0.196
All rs4148328 (T > C) 2 4.47 0.034 78 0.970 (0.638–1.476) 0.887 3.15 0.076 68 1.025 (0.634–1.658) 0.918 5.23 0.022 81 1.003 (0.509–1.973) 0.994 2.69 0.101 63 0.966 (0.685–1.361) 0.843
All rs3755319 (A > C) 2 0.36 0.551 0 1.258 (0.969–1.634) 0.084 0.01 0.932 0 0.637 (0.404–1.002) 0.051 0.02 0.882 0 0.737 (0.461–1.178) 0.203 0.06 0.813 0 1.454 (1.100–1.921) 0.009
China rs4148323 (G> A) 4 4.18 0.243 28 1.000 (0.791–1.265) 0.998 4.72 0.196 36 0.704 (0.347–1.426) 0.330 5.10 0.166 41 0.708 (0.333–1.505) 0.370 3.03 0.387 1 1.017 (0.842–1.227) 0.862
UGT2B7 China rs7662029 (A > G) 2 0.06 0.813 0 2.371 (1.779–3.160) <0.001 0.03 0.858 0 0.739 (0.444–1.231) 0.246 0.01 0.938 0 1.219 (0.715–2.077) 0.467 0.10 0.76 0 2.686 (1.988–3.627) <0.001
China rs7439366 (T > C) 2 0.35 0.554 0 0.347 (0.238–0.506) <0.001 0.00 0.950 0 0.675 (0.507–0.898) 0.007 0.11 0.739 0 0.338 (0.225–0.508) <0.001 0.59 0.443 0 0.359 (0.238–0.540) <0.001

UGT1A1, UDP-glucuronosyltransferase 1A1; UGT2B7, UDP-glucuronosyltransferase 2B7; AT-DILI, antituberculosis drug-induced liver injury; SNPs, single nucleotide polymorphisms; OR, odds ratio; 95% CI, 95% confidence interval.