Table 4.
Products containing cannabidiol (CBD) for the treatment of neurological disorders, along with their respective company names, mechanism of action, and adverse effects.
| Product name | Company name | Treated disorder | Mechanism of action | Adverse effects | Ref |
|---|---|---|---|---|---|
| Epidiolex | GW Pharmaceuticals | Seizures | Modulates calcium levels in the brain | Liver injury, suicidal thoughts, increased infections | [115] |
| Sativex | GW Pharmaceuticals | Multiple sclerosis | Activates cannabinoid receptors in the brain | Respiratory infections, cardiovascular events, cognitive effects | [116] |
| Nabiximols | Bayer | Multiple sclerosis | Enhances endocannabinoid signaling | Cognitive impairments, psychosis, dependency | [116] |
| CBD oral solution | Perrigo | Seizures | Modulates the endocannabinoid system | Liver toxicity, changes in mood, low blood pressure | [117] |
| Green Roads CBD | Green Roads | Stress | Interacts with cannabinoid receptors in the body | Changes in mood, respiratory issues, allergic reactions | [118] |
| Charlotte's Web | Charlotte's Web | Epilepsy | Activates cannabinoid receptors in the brain | Nausea, vomiting, liver problems, potential drug interactions | [119] |
| PlusCBD Oil | CV Sciences | Sleep disorders | Enhances endocannabinoid system functioning | Changes in appetite, liver damage, changes in blood pressure | [22] |
| Joy Organics | Joy Organics | Stress and anxiety | Modulates endocannabinoid receptors | Gastrointestinal issues, liver toxicity, changes in appetite | [120] |
| Veritas Farms | Veritas Farms | Depression | Activates cannabinoid receptors in the brain | Respiratory issues, changes in mood, potential drug interactions | [121] |
| Hemp Bombs | Hemp Bombs | Anxiety, epilepsy | Enhances endocannabinoid system functioning | Gastrointestinal issues, liver toxicity, changes in blood pressure | [122] |
| PureKana | PureKana | Anxiety, depression | Interacts with cannabinoid receptors in the body | Respiratory issues, changes in mood, potential drug interactions | [123] |
| Royal CBD | Royal CBD | Anxiety, depression, Alzheimer's disease | Modulates endocannabinoid receptors | Gastrointestinal issues, liver toxicity, changes in appetite | [124] |
| CBDfx | CBDfx | Stress and anxiety | Activates cannabinoid receptors in the brain | Respiratory issues, changes in mood, potential drug interactions | [67] |
| Bluebird Botanicals | Bluebird Botanicals | Stress and anxiety | Enhances endocannabinoid system functioning | Gastrointestinal issues, liver toxicity, changes in blood pressure | [125] |
| NuLeaf Naturals | NuLeaf Naturals | Anxiety, depression | Interacts with cannabinoid receptors in the body | Respiratory issues, changes in mood, potential drug interactions | [126] |
| Koi CBD | Koi CBD | Anxiety | Modulates endocannabinoid receptors | Gastrointestinal issues, liver toxicity, changes in appetite | [127] |
| CBD American Shaman | CBD American Shaman | Stress and anxiety | Activates cannabinoid receptors in the brain | Respiratory issues, changes in mood, potential drug interactions | [128] |
| Funky Farms | Funky Farms | Stress and anxiety | Enhances endocannabinoid system functioning | Gastrointestinal issues, liver toxicity, changes in blood pressure | [129] |
| Medterra CBD | Medterra CBD | Anxiety | Interacts with cannabinoid receptors in the body | Respiratory issues, changes in mood, potential drug interactions | [130] |
| CBD Living | CBD Living | Anxiety, depression, epilepsy | Modulates endocannabinoid receptors | Gastrointestinal issues, liver toxicity, changes in appetite | [131] |
| CBDfx Gummies | CBDfx | Depression | Activates cannabinoid receptors in the brain | Respiratory issues, changes in mood, potential drug interactions | [67] |
| JustCBD | JustCBD | Anxiety, depression | Enhances endocannabinoid system functioning | Gastrointestinal issues, liver toxicity, changes in blood pressure | [22] |
| Penguin CBD | Penguin CBD | Anxiety, depression | Interacts with cannabinoid receptors in the body | Respiratory issues, changes in mood, potential drug interactions | [79] |
| Lord Jones | Lord Jones | Anxiety | Modulates endocannabinoid receptors | Gastrointestinal issues, liver toxicity, changes in appetite | [132] |
| CBDMD | CBDMD | Stress and anxiety | Activates cannabinoid receptors in the brain | Respiratory issues, changes in mood, potential drug interactions | [67] |
| HempFusion | HempFusion | Depression, anxiety, posttraumatic stress disorder, Alzheimer's disease | Interacts with cannabinoid receptors in the body | Respiratory issues, changes in mood, potential drug interactions | [133] |