Table 2. Diagnostic yield for intrapulmonary malignant lesions of the combined EBUS-TBNA/EUS-B-FNA among the distinct studies.
| Study | Type of study | Patient numbers | Method | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|
| Herth FJ et al. (7) | Prospective | 139 | EBUS-TBNA + EUS-B-FNA | 96 | 100 | 100 | 95 |
| Hwangbo B et al. (8) | Prospective | 143 | EBUS-TBNA + EUS-B-FNA | 91 | 100 | 100 | 96 |
| Lee KJ et al. (14) | Retrospective | 37 | EBUS-TBNA + EUS-B-FNA | 100 | 100 | 100 | 100 |
| Oki M et al. (24) | Prospective | 146 | EBUS-TBNA + EUS-B-FNA | 73 | 100 | 100 | 93 |
| Szlubowski A et al. (25) | Prospective | 106 | EBUS-TBNA + EUS-B-FNA | 68 | 96 | 95 | 73 |
| Crombag LMM et al. (26) | Prospective | 220 | EBUS-TBNA + EUS-B-FNA | 82 | 87 | 82 | 87 |
| Chrysikos S et al. (27) | Prospective | 39 | EBUS-TBNA + EUS-B-FNA | 100 | 100 | – | – |
| Chrysikos S et al. (28) | Prospective | 130 | EBUS-TBNA + EUS-B-FNA | 93.8 | 100 | 100 | 93.4 |
| Kang HJ et al. (29) | Prospective | 74 | EBUS-TBNA + EUS-B-FNA (EBUS-centered) | 85.3 | 100 | 100 | 88.9 |
| 74 | EUS-B-FNA + EBUS-TBNA (EUS-centered) | 92 | 100 | 100 | 96.1 | ||
| Mondoni M et al. (31) | Prospective | 99 | EBUS-TBNA + EUS-B-FNA | 95.2 | 100 | – | – |
| Araya T et al. (34) | Prospective | 14 | EUS-B-FNA independent | 100 | 100 | – | – |
| 5 | EBUS-TBNA + EUS-B-FNA | 100 | 100 |
EUS-B-FNA, endoscopic ultrasound with bronchoscope-guided fine-needle aspiration; EBUS-TBNA, endobronchial ultrasound-transbronchial needle aspiration; PPV, positive predictive value; NPV, negative predictive value.