FIG. 6.

Intracellular stability of phosphate esters of nucleoside analogs in virus-infected MRC-5 cells. MRC-5 cells infected with HSV-1 (1), HSV-2 (2), or VZV (3) were treated with [³H]A-5021 (a) [³H]ACV (b), or [³H]PCV (c) at the concentrations shown for 5 h (HSV-1 and HSV-2) or 6 h (VZV). After extracellular compounds were removed, the levels of intracellular phosphate esters were analyzed by HPLC. Open circles, triphosphate; closed triangles, diphosphate; closed squares, monophosphate. T_1/2, half-life.