Table 1.
Characteristics of enrolled patients
| All patients (n = 203) | CRT (n = 50) | No CRT (n = 153) | |
|---|---|---|---|
| Age (years) | 60 [49–70] | 63 [52–73] | 59 [49–70] |
| Sex (female) | 71 (35%) | 15 (30%) | 56 (37%) |
| BMI (kg/m2) | 26.1 [23.5–30.7] | 25.6 [23.5–27.8] | 26.1 [23.4–31.2] |
| SOFA score | 4 [3–6] | 5 [3–6] | 4 [3–6] |
| Charlson comorbidity Index | 2 [1–4] | 2 [1–3] | 2 [1–4] |
| ICU admission reason | |||
| Medical | 178 (88%) | 45 (90%) | 133 (87%) |
| ARDS COVID | 56 (28%) | 19 (38%) | 37 (25%) |
| Septic shock | 41 (20%) | 9 (18%) | 32 (21%) |
| ARDS | 17 (8%) | 6 (12%) | 11 (7%) |
| Cardiac arrest | 17 (8%) | 3 (6%) | 14 (9%) |
| Acute liver failure | 7 (4%) | 2 (4%) | 5 (3%) |
| Othersa | 40 (20%) | 6 (12%) | 34 (22%) |
| Surgical | 25 (12%) | 5 (10%) | 20 (13%) |
| Trauma | 6 (3%) | 2 (4%) | 4 (3%) |
| Othersb | 19 (9%) | 3 (6%) | 16 (10%) |
| Laboratory data at enrollment | |||
| Hct (%) | 33 [28–38] | 32 [29–38] | 33 [27–38] |
| Platelets (103/mm3) | 202 [129–269] | 199 [141–254] | 207 [121–270] |
| INR | 1.19 [1.08–1.46] | 1.2 [1.07–1.48] | 1.19 [1.12–1.36] |
| aPTT Ratio | 0.95 [0.85–1.09] | 0.95 [0.86–1.09] | 0.94 [0.84–1.1] |
| Fibrinogen (mg/dL) | 436 [264–643] | 421 [245–642] | 523 [313–657] |
| D-dimers (mg/dL) | 3585 [1436–10476] | 3585 [1357–12300] | 3586 [1677–6484] |
| Anticoagulation during ICU stay | 185 (91%) | 48 (96%) | 137 (90%) |
| Prophylaxis | 105 (52%) | 26 (52%) | 79 (52%) |
| Therapy | 80 (39%) | 22 (44%) | 58 (38%) |
| Antiplatelet therapy during ICU stay | 43 (21%) | 8 (16%) | 35 (23%) |
| Monotherapy | 32 (16%) | 7 (14%) | 25 (16%) |
| Double | 11 (5%) | 1 (2%) | 10 (7%) |
| ECMO | 21 (10%) | 4 (8%) | 17 (11%) |
| Surgical interventionc | 53 (26%) | 12 (24%) | 41 (27%) |
| N. Catheters during ICU stay | 2 [1, 2] | 2 [1, 2] | 2 [2–2] |
| 1 | 85 (42%) | 9 (18%) | 76 (50%) |
| 2 | 80 (39%) | 29 (58%) | 51 (33%) |
| 3 | 27 (13%) | 9 (18%) | 18 (12%) |
| 4 | 7 (3%) | 2 (4%) | 5 (3%) |
| 5 | 3 (2%) | 0 (0%) | 3 (2%) |
| 6 | 1 (1%) | 1 (2%) | 0 (0%) |
CRT Catheter-related thrombosis, BMI, Body Mass Index, SOFA, Sequential Organ Failure Assessment; ICU, Intensive Care Unit; ARDS, Acute Respiratory Distress Syndrome; COVID, Coronavirus Disease; Hct, Hematocrit; INR, International Normalized Ratio; aPTT, activated partial thromboplastin time; ECMO, Extracorporeal Membrane Oxygenation
aIncluding asthma and chronic obstructive pulmonary disease exacerbation, cardiogenic shock, diabetic ketoacidosis, hypoglycemic coma, intoxication, heat stroke, botulinum poisoning, and status epilepticus
bIncluding lung and liver transplantation, bowel perforation and osteomyelitis
cIncluding patients admitted to ICU for surgical disease and patients who needed surgery during ICU stay for any reason