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Summary of the results obtained for the two complexes: [99mTc]Tc-O-TRENOX and [99mTc]Tc-O-TRENSOX
| Chelate | Duration of synthesis at RT (min) | Solvent use | Mean RCP (%) | Mean RCP at 24 h (%) | Charge | Log P | Elimination |
|---|---|---|---|---|---|---|---|
| O-TRENOX (4) | 5 | Ethanol | 98.3 ± 0.2 | 96.0 ± 0.5 | Neutral |
1.2 ± 0.2 Lipophilic |
Hepatic and gallbladder |
| O-TRENSOX (5) | 5 | Water | 97.6 ± 0.8 | 95.2 ± 0.4 | Negative |
− 2.3 ± 0.2 Hydrophilic |
Urinary and gallbladder |
