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. 2023 Oct 20;13:323. doi: 10.1038/s41398-023-02622-z

Table 2.

Relationships of polygenic scores for sleep duration, short-sleep, and long-sleep with the onset of depression during an average 8-year follow-up.

Models Depression
OR (SE) 95% CI p
Polygenic score for sleep duration
 Model 1: Unadjusted modela 0.914 (0.041) 0.838–0.997 0.044*
 Model 2: Model 1 + age, age2, sex, and 10 PCs 0.916 (0.041) 0.839–1.001 0.053
Polygenic score for short-sleep
 Model 1: Unadjusted modela 1.122 (0.051) 1.027–1.226 0.011*
 Model 2: Model 1 + age, age2, sex, and 10 PCs 1.140 (0.056) 1.035–1.255 0.008*
Polygenic score for long-sleep
 Model 1: Unadjusted modela 0.968 (0.043) 0.887–1.057 0.466
 Model 2: Model 1 + age, age2, sex, and 10 PCs 0.973 (0.044) 0.890–1.063 0.544

PCs principal components, OR (odds ratio), SE standard error, CI confidence interval, p significance value.

aBaseline caseness of outcomes was omitted from analyses. Alpha values have been adjusted to account for multiple testing. *significance at <0.001.