Table 2.
Relationships of polygenic scores for sleep duration, short-sleep, and long-sleep with the onset of depression during an average 8-year follow-up.
| Models | Depression | ||
|---|---|---|---|
| OR (SE) | 95% CI | p | |
| Polygenic score for sleep duration | |||
| Model 1: Unadjusted modela | 0.914 (0.041) | 0.838–0.997 | 0.044* |
| Model 2: Model 1 + age, age2, sex, and 10 PCs | 0.916 (0.041) | 0.839–1.001 | 0.053 |
| Polygenic score for short-sleep | |||
| Model 1: Unadjusted modela | 1.122 (0.051) | 1.027–1.226 | 0.011* |
| Model 2: Model 1 + age, age2, sex, and 10 PCs | 1.140 (0.056) | 1.035–1.255 | 0.008* |
| Polygenic score for long-sleep | |||
| Model 1: Unadjusted modela | 0.968 (0.043) | 0.887–1.057 | 0.466 |
| Model 2: Model 1 + age, age2, sex, and 10 PCs | 0.973 (0.044) | 0.890–1.063 | 0.544 |
PCs principal components, OR (odds ratio), SE standard error, CI confidence interval, p significance value.
aBaseline caseness of outcomes was omitted from analyses. Alpha values have been adjusted to account for multiple testing. *significance at <0.001.