Table 1.

Patient demographics and tumor profiles

Patient no	Sex	Age at initial neuroblastoma diagnosis	INSS stage at initial presentation	INRGSS stage	MYCN amplification	1p deletion	Primary tumor site	Macroscopic complete resection	Pathological findings of resected metastasis	Classification
1	m	6 mo	4	M	No	No	Left adrenal gland	Yes	Penile metastasis: 10 g heavy nodular soft tissue excidate, 4.2 × 2.2 × 1.9 cm manifestation of differentiating neuroblastoma. No evidence of necrosis. Low mitotic and karyorrhexis index according to INPC classification	Hughes: Neuroblastoma 1a. Regression grade 4. Differentiation grade 2
2	m	2 y 6 mo	4	M	No	No	Left adrenal gland	Yes	Ulnar bone metastasis: 8.6 × 3.1 × 1.6 cm soft tissue excidate. Soft tissue manifestation of neuroblastoma with approximately 90% tumor viability	Hughes: Neuroblastoma grade 1a. Regression grade 4. Differentiation grade 2
3	w	6 y 2 mo	4	M	Yes	No	Right adrenal gland	Yes	Pancreatic metastasis: 1.1 cm diameter manifestation of the Lineuroblastoma, removed in sano, approximately 50% vital. The margins are tumor-free. Poorly differentiated, low stroma neuroblastoma with low mitosis and karyorrhexis index according to INPC with severe pleomorphism, partly in the form of pancreatic, liver and lymph node metastases, with hemangio- and lymphangioinfiltration. Liver metastasis: 80% vital, predominantly increased mature imposing compared to primary tumor	Hughes: Neuroblastoma grade 3. Regression grade 4. Differentiation grade 4

INSS International Neuroblastoma Staging System, INRGSS International Neuroblastoma Risk Group Staging System