TABLE 2.

Structures and in vitro activities of para-substituted symmetrical furans

Compound	Y1	Y2a	R1	R2	C. albicans		C. neoformans
					MIC (μg/ml)	MFC (μg/ml)	MIC (μg/ml)	MFC (μg/ml)
Amphotericin B					1.0b	NTc	1.0b	NT
Fluconazole					0.25	NAd	2.0	NA
16	NH	NH2	H	H	6.25	25	12.5	25
17	NH	NH2	CH3	CH3	6.25	6.25	3.12	3.12
18	NOCH3	NH2	H	H	>100	NT	>100	NT
19	NH	NH-cPr	H	H	25	25	3.12	50
20	NH	NH-cBt	H	H	6.25	>50	0.78	6.25
21	NH	NH-cPt	H	H	6.25	25	0.78	6.25
22	NH	NH-cHx	H	H	12.5	12.5	1.56	6.25
23	NH	NH-CH2-cPr	H	H	6.25	25	0.78	6.25
24	NH	NH-CH2)2CH3	H	H	12.5	12.5	1.56	6.25
25	NH	NH-CH(CH3)2	H	H	25	50	6.25	50
26	NH	NH-CH(CH2CH3)2	H	H	100	100	12.5	12.5
27	NH	NH-CH2-CH(CH3)2	H	H	12.5	NT	3.12	12.5
28	NH	NH-(CH2)2-CH(CH3)2	H	H	12.5	12.5	6.25	12.5
29	NH	NH-(CH2)3-Pyr	H	H	100	NT	6.25	25
30	NH	NH-(CH2)3PipCH3	H	H	>100	NT	12.5	50
31	NH	NH-(CH2)4-NH(CH3)2	H	H	12.5	25	≤0.09	0.19
32	NH	NH-(CH2)6-NH(CH3)2	H	H	>100	NT	1.56	3.12
33		ONH-(CH2)3Oxz	H	H	>100	NT	>100	NT
34		ONH-(CH2)2-NH(CH3)2	H	H	>100	NT	>100	NT
35		ONH-(CH2)3-NH(CH3)2	H	H	>100	NT	>100	NT
36		ONH-(CH2)3-NHCH3Ph	H	H	>100	NT	>100	NT
37		ONCH3-(CH2)3-NH(CH3)2	H	H	>100	NT	>110	NT

^a 

^bSee footnote b of Table 1. 

^cNT, not tested. 

^dNA, no activity.