TABLE 5.

Structures and in vitro activities of benzimidazoles        

Compound	Ya	Ra	C. albicans		C. neoformans
			MIC (μg/ml)	MFC (μg/ml)	MIC (μg/ml)	MFC (μg/ml)
Amphotericin B			1.0b	NTc	1.0b	NT
Fluconazole			0.25	NAd	2.0	NA
48	BzIm	OH	3.12	NT	3.12	NT
49	BzIm	OCH3	0.78	NT	3.12	3.12
50	BzIm	OC2H5	0.78	12.5	1.56	1.56
51	BzTHP	OH	3.12	25	1.56	6.25
52	BzAm	OH	0.78	6.25	3.12	6.25
53	BzAm	Am	0.39	1.56	≤0.09	0.78
54	BzIm	Im	0.78	1.56	0.39	0.39
55	BzAm	OCH3	>100	NT	3.12	>25
56	BzTHP	THP	0.78	1.56	0.19	0.39
57	BzAm	OC2H5	0.78	1.56	1.56	1.56
58	BzMPZ	OH	25	50	100	>100
59	Im	OCH3	25	NT	50	100
60	Am	Am	100	>100	25	50
61	Am	OH	>100	NT	>100	>100
62	Im	Im	50	>100	50	NT
63	THP	THP	50	100	25	50
64	Am	O(CH2)3OPhAm	0.39	0.78	0.19	0.78
65	Am	O(CH2)4OPhAm	0.39	3.12	≤0.09	1.56
66	Am	O(CH2)5OPhAm	0.78	1.56	0.39	6.25
67	Am	OPhAm	0.78	0.78	0.78	6.25

^a 

^bSee footnote b of Table 1. 

^cNT, not tested. 

^dNA, no activity.