Table 4.
Correlation of intrinsic subtype, tumor size, lymph node metastasis, and MRI-negative predictive value
| Prevalence of LN metastasis N (%) | NPV of MRI %(95%CI) | Average FN LNa | N1 N (%) | N2 N (%) | N3 N (%) | |
|---|---|---|---|---|---|---|
| Total | 861/2473 (34.8) | 77.7 (76.7–81.1) | 2.3 | 276 (87.1) | 31 (9.8) | 10 (3.2) |
| Luminal A | 275/932 (29.5) | 79.7 (76.7–83.3) | 1.7 | 116 (91.3) | 11 (8.7) | 0 |
| P size ≤ 2 cm | 107/557 (19.2) | 86.6 (82.7–89.9) | 1.5 | 58 (95.1) | 3 (4.9) | 0 |
| P size ≤ 3 cm | 203/792 (25.6) | 82.5 (78.9–85.8) | 1.5 | 96 (94.1) | 6 (5.9) | 0 |
| MRI size ≤ 2 cm | 53/314 (16.9) | 76.4 (67.9–83.6) | 1.5 | 30 (96.8) | 1 (3.2) | 0 |
| MRI size ≤ 3 cm | 123/580 (21.2) | 85.6 (81.7–88.9) | 1.5 | 59 (95.2) | 3 (4.8) | 0 |
| Luminal B1 | 313/760 (41.2) | 73.5 (70.0–78.0) | 2.7 | 91 (84.3) | 10 (9.3) | 7 (6.5) |
| P size ≤ 2 cm | 95/339 (28.0) | 81.7 (75.6–86.8) | 1.6 | 40 (95.2) | 2 (4.8) | 0 |
| P size ≤ 3 cm | 195/570 (34.2) | 78.4 (73.3–82.9) | 1.5 | 72 (94.7) | 4 (5.3) | 0 |
| MRI size ≤ 2 cm | 35/173 (20.2) | 88.1 (80.9–93.4) | 1.7 | 18 (94.7) | 1 (5.3) | 0 |
| MRI size ≤ 3 cm | 131/424 (30.9) | 79.6 (74.0–84.5) | 1.7 | 54 (94.7) | 2 (3.5) | 1 (1.8) |
| Luminal B2 | 134/307 (43.6) | 71.7 (64.7–79.8) | 2.1 | 38 (88.4) | 4 (9.3) | 1 (2.3) |
| P size ≤ 2 cm | 35/138 (25.4) | 83.5 (73.5–90.9) | 2.5 | 14 (87.5) | 1 (6.3) | 1 (6.3) |
| P size ≤ 3 cm | 90/240 (37.5) | 76.9 (68.3–84.0) | 2.0 | 31 (91.2) | 2 (5.9) | 1 (2.9) |
| MRI size ≤ 2 cm | 8/42 (19.0) | 84.4 (67.2–94.7) | 2.2 | 4 (80.0) | 1 (20.0) | 0 |
| MRI size ≤ 3 cm | 49/145 (33.8) | 79.8 (69.6–87.7) | 2.6 | 18 (85.7) | 2 (9.5) | 1 (4.8) |
| HER-2 | 53/176 (30.1) | 76.4 (66.2–84.8) | 2.4 | 15 (83.3) | 2 (11.1) | 1 (5.6) |
| P size ≤ 2 cm | 14/87 (16.1) | 82.8 (69.1–90.9) | 1.3 | 8 (100.0) | 0 | 0 |
| P size ≤ 3 cm | 32/136 (23.5) | 79.7 (69.7–87.3) | 1.6 | 13 (92.9) | 1 (7.1) | 0 |
| MRI size ≤ 2 cm | 2/18 (11.1) | 90.1 (74.6–98.1)* | 1.0 | 1 (100.0) | 0 | 0 |
| MRI size ≤ 3 cm | 11/56 (19.6) | 78.9 (62.7–90.4) | 1.3 | 7 (100.0) | 0 | 0 |
| TNBC | 57/192 (29.7) | 86.4 (77.4–92.8) | 3.7 | 12 (80.0) | 2 (13.3) | 1 (6.7) |
| P size ≤ 2 cm | 14/90 (15.6) | 92.5 (81.8–97.9)* | 1.6 | 6 (100.0) | 0 | 0 |
| P size ≤ 3 cm | 33/147 (22.4) | 91.7 (82.7–96.9)* | 1.3 | 8 (100.0) | 0 | 0 |
| MRI size ≤ 2 cm | 5/35 (14.3) | 92.3 (74.9–99.1)* | 1.0 | 2 (100.0) | 0 | 0 |
| MRI size ≤ 3 cm | 16/81 (19.8) | 92.3 (81.5–97.9)* | 1.4 | 5 (100.0) | 0 | 0 |
NPV negative predict value, FN false negative, LN lymph node, P size pathological size, TNBC triple-negative breast cancer
*NPV > 90%