On-treatment mR-scores correlated with response. (A) Weak correlation between on-treatment and pretreatment mR-scores. Spearman correlation coefficient R = 0.39 (p = 0.003). (B) On-treatment mR-scores in patients receiving different NAC regimens.
DDMVAC + CYST = dose-dense methotrexate, vinblastine, adriamycin, and cisplatin followed by cystectomy; GC + CYST = gemcitabine-cisplatin followed by cystectomy; mR-score = methylation-based response score; NAC = neoadjuvant chemotherapy; NR = nonresponder; R = responder.