TABLE 4.
Estimation of PK/PD parameters derived from the inhibitory sigmoidal Emax model.
| PK/PD parameter | E0 (log10 CFU/mL) | EC50 | Emax (log10 CFU/mL) | Hill coefficient | R2 | 3 Log10 CFU/mL reduction |
|---|---|---|---|---|---|---|
| Enrofloxacin alone | ||||||
| AUC24h/MIC (h) | −3.64 | 24.00 | 2.90 | 5.51 | 0.917 | 23.29 |
| Cmax/MIC | −4.60 | 3.92 | 3.06 | 2.09 | 0.951 | 3.18 |
| %T > MIC | −5.90 | 72.47 | 2.67 | 4.28 | 0.936 | 62.71 |
| Cefquinome alone | ||||||
| AUC24h/MIC (h) | −1.81 | 6.06 | 2.25 | 29.19 | 0.957 | 6.28 |
| Cmax/MIC | −1.81 | 4.01 | 2.25 | 10.25 | 0.948 | 4.44 |
| %T > MIC | −2.32 | 46.50 | 2.32 | 13.28 | 0.995 | 48.66 |
| Cefquinome in combination with enrofloxacin | ||||||
| AUC24h/MIC (h) | −2.98 | 5.06 | 2.29 | 3.82 | 0.941 | 4.78 |
| Cmax/MIC | −2.84 | 2.42 | 2.25 | 14.78 | 0.936 | 2.54 |
| %T > MIC | −3.35 | 17.43 | 2.32 | 3.41 | 0.959 | 18.04 |
Emax is the change in the control group (log10 CFU/mL) from 0 h to 24 h; E0 is the maximum value of the antibacterial effect; EC50 is the corresponding PK/PD, index that produces a 50% reduction of the maximum antibacterial effect; N is the Hill coefficient. The “3 Log10 CFU/mL reduction” is the PK/PD, index value calculated after a decrease of 3 Log10 CFU/mL in Emax.