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. 2023 Oct 19;12(10):e12361. doi: 10.1002/jev2.12361

FIGURE 7.

FIGURE 7

FV@CX5461 alleviated IMQ‐induced psoriasis. (a) Schematic diagram for i.v. administration of drugs on day 4, day 5, and day 6 during the application of IMQ on a daily basis. (b) In vivo distribution of GEVs, NVs, CCR6‐NVs, and FV@CX5461 in IMQ‐induced psoriasis mice. (c) PASI scores of mice in each group over 7 days of the experiment (n = 5). (d) Representative images of mouse dorsal skin in each group on day 7. (e) H&E staining and immunohistochemistry of lesional skins in each group of mice on day 7. Scale bar: 100 μm. (f,g) Representative flow cytometric analysis of CD3+ T cells, CD4+ T cells, CD4+ IL17+ T cells, and CD4+ CD25+ Foxp3+ Treg cells in spleens (n = 3). (h) ELISA assay to detect IL‐1β, TNF‐α, IL‐17, IL‐22, and IL‐12/23 p40 in the serum of each group of mice on day 7 (n = 3). Error bar, mean ± SD. n.s represents no significant, **P < 0.01; ***P < 0.001.