Dysregulated AG/LEAP-2 balance in patients with AN
BMI (A) increased with refeeding during hospitalization in 30 patients with AN. AG levels (expressed in pmol/L, B) were significantly decreased with refeeding. LEAP-2 levels were also significantly decreased with refeeding (C). AG/LEAP-2 molar ratio (D) decreased after refeeding compared to undernourished state. Data are expressed as mean ± SEM plus individual values and were analyzed using paired Student’s t test: ∗p < 0.05, ∗∗∗∗p < 0.0001. BMI: Body mass Index (kg/m2), AG: Acyl-ghrelin. LEAP-2: Liver-expressing Antimicrobial Peptide-2. V1: undernourished state at admission; V2: refed state at discharge.