TABLE 5.

Diagnostic performance of interocular asymmetry values and combined models for distinguishing the control from KC or SKC.

	Control vs. KC (training dataset)				Control vs. KC (validation dataset)				Control vs. SKC subgroup
Interocular asymmetry parameters	Cutoff	AUC	Sensitivity	Specificity	Cutoff	AUC	Sensitivity	Specificity	Cutoff	AUC	Sensitivity	Specificity
Δ Pachy [μm]	16.5	0.875	0.730	0.958	17.5	0.878	0.746	0.922	16.5	0.786	0.591	0.939
Δ A1T [ms]	0.150	0.652	0.533	0.729	0.190	0.636	0.394	0.878	0.194	0.580	0.290	0.873
Δ A1V [m/s]	0.016	0.714	0.489	0.871	0.016	0.745	0.549	0.911	0.016	0.621	0.376	0.882
Δ A2T [ms]	0.162	0.609	0.701	0.483	0.149	0.641	0.746	0.533	0.197	0.600	0.591	0.612
Δ A2V [m/s]	0.048	0.673	0.365	0.938	0.051	0.689	0.338	0.989	0.054	0.581	0.204	0.970
Δ HCT [ms]	0.236	0.531	0.737	0.362	0.766	0.490	0.254	0.911	0.215	0.528	0.796	0.285
Δ PD [mm]	0.126	0.576	0.518	0.637	0.141	0.517	0.507	0.633	0.126	0.551	0.516	0.615
Δ A1DeflAmp [mm]	0.013	0.676	0.401	0.967	0.013	0.741	0.408	0.978	0.013	0.568	0.194	0.970
Δ HCDeflAmp [mm]	0.068	0.761	0.620	0.808	0.050	0.731	0.761	0.611	0.053	0.680	0.613	0.676
Δ A2DeflAmp [mm]	0.016	0.683	0.460	0.854	0.020	0.600	0.324	0.911	0.005	0.547	0.742	0.358
Δ A1DeflArea [mm2]	0.046	0.572	0.263	0.867	0.042	0.599	0.366	0.844	0.024	0.505	0.462	0.573
Δ HCDeflArea [mm2]	0.430	0.646	0.431	0.858	0.102	0.602	0.803	0.356	0.266	0.603	0.581	0.606
Δ A2DeflArea [mm2]	0.064	0.577	0.307	0.8211	0.041	0.587	0.507	0.644	0.034	0.527	0.559	0.521
Δ A1ΔArcL [mm]	0.004	0.691	0.474	0.854	0.004	0.694	0.535	0.856	0.004	0.620	0.333	0.855
Δ HCΔArcL [mm]	0.014	0.650	0.650	0.625	0.026	0.676	0.451	0.856	0.013	0.640	0.656	0.582
Δ A2ΔArcL [mm]	0.005	0.644	0.431	0.838	0.007	0.643	0.366	0.933	0.005	0.615	0.441	0.739
Δ MaxIR [mm-1]	0.020	0.828	0.686	0.887	0.016	0.870	0.789	0.844	0.016	0.786	0.688	0.815
Δ DAR2	0.300	0.907	0.781	0.921	0.299	0.923	0.859	0.889	0.300	0.874	0.688	0.912
Δ DAR1	0.046	0.820	0.620	0.938	0.053	0.839	0.662	0.922	0.047	0.748	0.473	0.921
Δ ARTh	132.542	0.778	0.628	0.858	104.008	0.788	0.775	0.756	128.893	0.753	0.570	0.836
Δ bIOP [mmHg]	0.950	0.583	0.569	0.608	1.650	0.544	0.310	0.844	1.350	0.555	0.430	0.718
Δ IR [mm-1]	0.945	0.903	0.745	0.908	1.185	0.928	0.732	0.978	1.140	0.866	0.602	0.952
Δ SP-A1	13.474	0.804	0.679	0.808	14.270	0.812	0.676	0.867	14.044	0.702	0.505	0.833
Δ SSI	0.084	0.694	0.628	0.708	0.100	0.691	0.592	0.778	0.085	0.637	0.570	0.700
BBI	0.477	0.952	0.854	0.971	0.493	0.954	0.901	0.956	0.190	0.913	0.828	0.894
MBI	0.513	0.961	0.854	0.967	0.421	0.970	0.887	0.956	0.484	0.968	0.849	0.988
BaBI	0.401	0.998	0.978	0.992	0.579	0.995	0.986	0.956	0.163	0.996	0.978	0.958
CBI	0.147	0.935	0.856	0.945	0.194	0.954	0.887	0.967	0.112	0.925	0.828	0.967
TBI	0.720	0.962	0.837	0.994	0.857	0.965	0.859	1.000	0.318	0.965	0.880	0.973
PRFI	0.442	0.965	0.909	0.988	0.502	0.968	0.915	0.989	0.296	0.969	0.924	0.991

KC, keratoconus; SKC, subclinical keratoconus; AUC, area under the receiver operating characteristic curve.