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. 2023 Oct 6;13:1276976. doi: 10.3389/fonc.2023.1276976

Table 4.

Safety signals of sacituzumab govitecan in cases aged >65.

AE n ROR(95CI) IC(IC025)
Diarrhoea 22 4.65 (3.03-7.14) 4.48(2.92)
Disease progression 18 21.84 (13.64-34.99) 21.04(13.13)
Febrile neutropenia 16 31.92 (19.39-52.56) 30.85(18.73)
Sepsis 15 20.22 (12.09-33.82) 19.60(11.72)
Neutropenia 14 13.58 (7.98-23.12) 13.20(7.76)
Fatigue 11 1.82 (1.00-3.30) 1.80(0.99)
Thrombocytopenia 9 11.78 (6.09-22.79) 11.57(5.98)
Asthenia 8 3.17 (1.57-6.37) 3.13(1.56)
Anaemia 8 6.27 (3.12-12.61) 6.18(3.07)
Death 7 1.12 (0.53-2.36) 1.12(0.53)
Hypotension 7 5.03 (2.38-10.61) 4.97(2.36)
Alopecia 6 3.83 (1.71-8.58) 3.80(1.70)
Colitis 6 20.03 (8.95-44.84) 19.78(8.84)
Vomiting 5 1.68 (0.69-4.05) 1.67(0.69)
Weight decreased 5 2.28 (0.95-5.52) 2.27(0.94)
Weight increased 5 2.98 (1.24-7.20) 2.96(1.23)
Acute kidney injury 5 3.29 (1.36-7.94) 3.27(1.35)
General physical health deterioration 5 5.34 (2.21-12.89) 5.29(2.19)
White blood cell count decreased 5 5.38 (2.23-12.98) 5.33(2.21)
Atrial fibrillation 5 6.91 (2.86-16.69) 6.85(2.84)
Septic shock 5 16.63 (6.89-40.15) 16.45(6.82)
Neutropenic sepsis 5 101.11 (41.83-244.43) 99.72(41.25)
Neutropenic colitis 5 282.05 (116.36-683.66) 276.45(114.05)
Pain 4 0.69 (0.26-1.84) 0.69(0.26)
Dyspnoea 4 0.99 (0.37-2.64) 0.99(0.37)
Rash 4 1.21 (0.45-3.23) 1.21(0.45)
Abdominal pain 4 2.48 (0.93-6.64) 2.47(0.92)
Nausea 3 0.56 (0.18-1.75) 0.57(0.18)
Condition aggravated 3 1.04 (0.33-3.23) 1.04(0.33)
Pyrexia 3 1.18 (0.38-3.67) 1.18(0.38)
Constipation 3 1.88 (0.60-5.85) 1.88(0.60)
Somnolence 3 2.23 (0.72-6.95) 2.22(0.71)
Urinary tract infection 3 2.28 (0.73-7.10) 2.27(0.73)
Hemoglobin decreased 3 4.34 (1.39-13.50) 4.32(1.39)
Myocardial infarction 3 4.43 (1.42-13.78) 4.41(1.42)
Stress 3 4.91 (1.58-15.27) 4.88(1.57)
Dysphagia 3 5.19 (1.67-16.15) 5.16(1.66)
Leukopenia 3 8.59 (2.76-26.72) 8.54(2.74)
Speech disorder 3 8.70 (2.79-27.07) 8.65(2.78)
Pneumonitis 3 14.10 (4.53-43.9) 14.01(4.50)
Mucosal inflammation 3 16.68 (5.36-51.92) 16.57(5.32)
Eating disorder 3 18.12 (5.82-56.41) 18.00(5.78)
Febrile bone marrow aplasia 3 121.33 (38.9-378.43) 120.07(38.50)