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Plasma and Thy/Liv implant ISIS 5320a concentrations after the administration of five daily subcutaneous doses
| Dosage (mg/kg/day) | Mouse no. | ISIS 5320 concn (μM)
|
|
|---|---|---|---|
| Plasma | Thy/Liv implant | ||
| 25 | 1 | 9.6 | 3.5 |
| 2 | 8.6 | NAb | |
| 3 | 11 | 5.3 | |
| 50 | 1 | 19 | NA |
| 2 | 21 | 8.2 | |
| 3 | 16 | 10 | |
Intact 8-mer oligonucleotide.
NA, not available.
