Table 1.

Efflux-pump variants in the carbapenem non-susceptible group.

Variant	p -value for the chi-squared test of significance		Specificity		Positive predictive value (PPV)		PROVEAN score	Prediction (−2.5 cutoff)
	Meropenem	Imipenem	Meropenem	Imipenem	Meropenem	Imipenem
AdeA Q335H	0.005	0.007	92.9	91.4	77.9	55	−1.703	Neutral
AdeB G283A	0.002	0	100	99.8	100	93.3	−5.593	Deleterious
AdeB A551T	0.017		74.9		69.9		−0.233	Neutral
AdeB T606A	0.019	0.022	91.5	90.7	75	53.2	−0.047	Neutral
AdeB L730F	0.013	——-	75	——	70.1	——	−2.401	Neutral
AdeC A19T	——–	0.019	——-	91.8	——–	54	−0.548	Neutral
AdeC D260N	0.001	0	92	90.9	79.5	58.2	0.037	Neutral
AdeR A136V	0.021	——-	74.5	——	69.5	——	−1.168	Neutral
AdeR I175L	0	0	94.3	94.3	82.9	71.4	1.206	Neutral
AdeR H158L	0.001	0.037	96.7	94.8	85.1	55.4	−2.425	Neutral
AdeS L105F	0	——	100	——	100	—–	−3.954	Deleterious
AdeS N125K	——-	0.009	——-	99.6	——-	81.8	−2.997	Deleterious
AdeS A130V	——	0.002	——–	99.6	——–	84.6	−3.963	Deleterious
AdeS G186V	0.002	0.039	75	66.7	71.7	47.3	−8.183	Deleterious
AdeS H189Y	0	0.019	97.6	95.4	88.6	57.4	−2.046	Neutral
AdeS V235I	0.011	—–	94.8	——	78.8	—–	−0.566	Neutral
AdeS I331V	——-	0	——-	86.3	——–	56.7	−0.723	Neutral
AdeS G336S	0.031	0.013	94.3	94.3	76.5	56.8	5.479	Neutral
AdeS V348I	0.002	——	74.5	—–	71.3	—–	0.156	Neutral
AdeS I360M	0.008	0.005	91.5	90.9	76.3	55.3	−0.093	Neutral
AdeI A388T	0	0.009	98.6	95.9	92.7	59.6	−0.548	Neutral
AdeN P16L	——-	0.004	——–	99.5	——-	80	−4.442	Deleterious
AdeN P92T	0	0	100	99.6	100	91.3	−0.423	Neutral
AdeN K216N	0	0	99.1	98.9	96.6	92.9	−1.339	Neutral
AdeG A350T	0.003	0.004	92.5	91.3	78.1	55.9	−1.770	Neutral
AdeF S172F	0.025	0.001	99.5	99.6	92.3	85.7	−2.494	Neutral
AdeL D227A	0	0.02	99.1	99.1	93.3	70.6	−4.373	Deleterious