Table 2.
Progress of clinical trials on sphingolipids and insulin resistance and related diseases.
| Study title | Conditions | Status | Year | Reference source |
|---|---|---|---|---|
| Brain Imaging Study of Rosiglitazone Efficacy and Safety in Alzheimer’s Disease | AD | Completed | 2005 | NCT00265148 |
| Rosiglitazone Effects on Cognition for Adults in Later Life | Mild Cognitive Impairment | Unknown | 2005 | NCT00242593 |
| Mutations Associated with Parkinson s Disease | PD | Terminated | 2012 | NCT01547832 |
| Effect of Insulin Sensitizer Metformin on AD Biomarkers | AD, Vascular Dementia, Dementia, Memory Impairment | Completed | 2013 | NCT01965756 |
| Alzheimer’s Disease Biomarkers in Cerebrospinal Fluid in Insulin-resistant Men | AD | Completed | 2013 | NCT02010476 |
| Palmitoleic Isomer Study | Insulin Sensitivity | Completed | 2014 | NCT02311790 |
| Macronutrient Effects on Alzheimer’s Disease (MEAL-2) | Prediabetic State, Insulin Resistance, Middle Age, (and 2 more…) | Completed | 2015 | NCT02463084 |
| Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain Function | AD, Obesity, Diabetes Mellitus | Completed | 2015 | NCT02460783 |
| BDPP Treatment for Mild Cognitive Impairment (MCI) and Prediabetes or Type 2 Diabetes Mellitus (T2 DM) | Mild Cognitive Impairment, AD | Completed | 2015 | NCT02502253 |
| Phospholipid and Sphingolipids Composition of High-density Lipoproteins (HDL) in Obese Non-diabetic Patients with Metabolic Syndrome | Metabolic Syndrome | Completed | 2016 | NCT02851602 |
| Serum Sphingolipidomic Analyses in Healthy, Diabetic and Prediabetic Subjects | Type 2 Diabetes Mellitus, Prediabetic State | Unknown | 2016 | NCT02826759 |
| Effects of Chromium on Insulin Resistance in Alzheimer Disease Patients | Alzheimer Disease | Unknown | 2017 | NCT03038282 |
| Skeletal Muscle Diacylglycerol and Sphingolipids-Impact of Localization and Species on Insulin Resistance in Humans | Type 2 Diabetes Mellitus, Pre-diabetes, Obesity | Completed | 2017 | NCT03077360 |
| Ceramides in Muscle During Insulin Resistance | Insulin Resistance | Withdrawn | 2018 | NCT03731598 |
| Plasma Dihydroceramides Are Associated with Hepatic Steatosis in Type 1 and Type 2 Diabetes | Type 2 Diabetes Mellitus, Type 1 Diabetes Mellitus | Completed | 2018 | NCT03447964 |
| Vanderbilt Memory and Aging Project | Alzheimer Disease, Aging, Aged, 80 and Over, (and 5 more…) | Recruiting | 2022 | NCT05372159 |