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. 2023 Oct 20;13(10):e1437. doi: 10.1002/ctm2.1437

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© 2023 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Validation of extrachromosomal circular DNAs (eccDNAs) in type 2 diabetes mellitus (T2DM) plasma samples. (A) The pipeline for eccDNA clusters analysis spans exon regions. (B) Top 30 unique exons presented in 135 unique eccGenes (Fisher's exact test). (C) Integrative Genomics Viewer (IGV) depicted for eccDNAs derived from the C20orf203 gene. Each sample was marked as “Post/Pre‐short‐term intensive insulin therapy (SIIT)”, the black bar on the bottom line represents for exon region, the thick line means the exon region, and the thin line means the intronic region; PCR validation of eccDNAs from C20orf203, which frequently derived eccDNAs in multiple samples. Junction sites were obtained after the sequencing of PCR products.