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. 2023 Oct 20;13(44):30753–30770. doi: 10.1039/d3ra05310e

Enzyme inhibition assay of the most active compounds against EGFR TK and CDK 2.

Compound	EGFR inhibition	CDK-2 inhibition
Compound	IC₅₀ nM ± SE^a	IC₅₀ nM ± SE^a
6d	362 ± 8	174 ± 164
6m	130 ± 11	402 ± 86
6o	62 ± 3	118 ± 16
Lapatinib	69 ± 4	—
Roscovitine	—	206 ± 10

^a

SE; standard error.