REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-Nrf2 Antibody A-10, use as , use as 1:40 dilution	Santa Cruz	Cat#sc-365949
APC-H7 Mouse Anti-Human CD3, use as 1:167 dilution	BD Pharmingen	Cat# 560275
BV711 Mouse Anti-Human CD4, use as 1:333 dilution	BD Horizon	Cat#563913
BUV805 Mouse Anti-Human CD8, use as 1:167 dilution	BD Horizon	Cat#612890
PE-CF594 Mouse Anti-Human CCR7 (CD197), use as 1:167 dilution	BD Horizon	Cat#566769
PE-Cy7 Mouse Anti-Human CD45RO, use as 1:40 dilution	BD Pharmingen	Cat#560608
Alexa Fluor 700 Mouse Anti-Human CD27, use as 1:20 dilution	BD Pharmingen	Cat#560611
BV786 Mouse Anti-Human CD19, use as 1:167 dilution	BD Horizon	Cat#563325
BV650 Mouse Anti-Human CD21, use as 1:80 dilution	BD OptiBuild	Cat#740569
BUV395 Mouse Anti-Human CD56, use as 1:167 dilution	BD Horizon	Cat#563554
SOD1/Cu-Zn SOD Antibody, , use as 1:25 dilution	Novus Biologicals	Cat#JF1005
Goat anti-Rabbit IgG (H + L) Secondary Antibody, DyLight 405, , use as 1:1,000 dilution	Thermo Fisher Scientific	Cat#35551
Biological samples
Cryopreserved human peripheral blood mononuclear cells (PBMCs)	Healthy volunteers	N/A
Chemicals, peptides, and recombinant proteins
Dulbecco’s phosphate-buffer saline (DPBS) solution without calcium and magnesium	Gibco	Cat#14190-144
RPMI 1640 Medium (RPMI)	Thermo Fisher	Cat#11875093
Penicillin-Streptomycin (10,000 U/mL)	Thermo Fisher	Cat#15140122
Fetal bovine serum (FBS)	EuroClone	EUS00AY
Distilled cell culture water	Gibco	Cat#A12873-01
Viability Dye - LIVE/DEAD Fixable Blue	Thermo Fisher Scientific	Cat#L34962
ThiolTracker Violet (TTV)	Thermo Fisher Scientific	Cat#T10096
MitoSOX RED	Thermo Fisher Scientific	Cat#M36008
MitoView Green (MVG)	Biotium	Cat#70054
Brilliant stain buffer	BD Horizon	Cat#566349
Stain buffer (BSA)	BD	Cat#554657
Foxp3 / Transcription Factor Fixation/Permeabilization Concentrate and Diluent kit	eBioscience	Cat#00-5521-00
Permeabilization buffer (10×)	eBioscience	Cat#00-8333-56
UltraComp eBeads Plus	Thermo Fisher	Cat#01-3333-42
ArC Reactive Beads	Thermo Fisher	Cat#A10346
DIVA CS&T RUO BEAD 150	BD	Cat#655051
Trypan blue	BioWhittaker	Cat#17-942E
H2O2 (3%)	DR MARCUS	02083626000200
Critical commercial assays
Menadione sodium bisulfite, approx. 95%	Sigma-Aldrich	M5750-25G
MG132	Sigma-Aldrich	M7449
Deposited data
Raw and analyzed data	This paper	N/A
Software and algorithms
FACSDiva 8.0.3	BD	659528
FlowJoTM v10 Software	FlowJo was acquired by BD	NA
BioRender: Scientific Image and Illustration Software – (Graphical abstract, Figure 1)	BioRender	NA